Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin

Patients with resistance to thyroid hormone (RTH) exhibit elevated thyroid hormone levels and inappropriate thyrotropin (thyroid-stimulating hormone, or TSH) production. The molecular basis of this disorder resides in the dominant inhibition of endogenous thyroid hormone receptors (TRs) by a mutant...

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Pubblicato in:	J Clin Invest
Autori principali:	Abel, E. Dale, Kaulbach, Helen C., Campos-Barros, Angel, Ahima, Rexford S., Boers, Mary-Ellen, Hashimoto, Koshi, Forrest, Douglas, Wondisford, Fredric E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1999
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9916139/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5205
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