Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

Influenza hemagglutinin (HA) is the primary target of the humoral response during infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies (bnAbs), thereby limiting their efficacy. Although several bnAbs bind to the conserved stem domain of HA,...

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Main Authors: Mallajosyula, Vamsee V. A., Citron, Michael, Ferrara, Francesca, Lu, Xianghan, Callahan, Cheryl, Heidecker, Gwendolyn J., Sarma, Siddhartha P., Flynn, Jessica A., Temperton, Nigel J., Liang, Xiaoping, Varadarajan, Raghavan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078824/
https://ncbi.nlm.nih.gov/pubmed/24927560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402766111
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