Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal Challenge

The hemagglutinin protein (HA) on the surface of influenza virus is essential for viral entry into the host cells. The HA1 subunit of HA is also the primary target for neutralizing antibodies. The HA2 subunit is less exposed on the virion surface and more conserved than HA1. We have previously desig...

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Bibliografiska uppgifter
Huvudupphovsmän: Bommakanti, Gayathri, Lu, Xianghan, Citron, Michael P., Najar, Tariq Ahmad, Heidecker, Gwendolyn J., ter Meulen, Jan, Varadarajan, Raghavan, Liang, Xiaoping
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Vaccines and Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503045/
https://ncbi.nlm.nih.gov/pubmed/23015722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01429-12
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