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Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron
Although the active site of group I introns is phylogenetically conserved, subclasses of introns have evolved different mechanisms of stabilizing the catalytic core. Large introns contain weakly conserved ‘peripheral’ domains that buttress the core through predicted interhelical contacts, while smal...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC407829/ https://ncbi.nlm.nih.gov/pubmed/15107495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh548 |
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