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Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron

Although the active site of group I introns is phylogenetically conserved, subclasses of introns have evolved different mechanisms of stabilizing the catalytic core. Large introns contain weakly conserved ‘peripheral’ domains that buttress the core through predicted interhelical contacts, while smal...

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Bibliografiset tiedot
Päätekijät: Lupták, Andrej, Doudna, Jennifer A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC407829/
https://ncbi.nlm.nih.gov/pubmed/15107495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh548
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