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The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence
Oncogene induced senescence (OIS) is a sustained anti-proliferative response acutely induced in primary cells via activation of mitogenic oncogenes such as Ras/BRAF. This mechanism acts as an initial barrier preventing normal cells transformation into malignant cell. Besides oncogenic activation and...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077769/ https://ncbi.nlm.nih.gov/pubmed/24984035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101064 |
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