Absolute Quantitation of Met Using Mass Spectrometry for Clinical Application: Assay Precision, Stability, and Correlation with MET Gene Amplification in FFPE Tumor Tissue

BACKGROUND: Overexpression of Met tyrosine kinase receptor is associated with poor prognosis. Overexpression, and particularly MET amplification, are predictive of response to Met-specific therapy in preclinical models. Immunohistochemistry (IHC) of formalin-fixed paraffin-embedded (FFPE) tissues is...

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Hauptverfasser: Catenacci, Daniel V. T., Liao, Wei-Li, Thyparambil, Sheeno, Henderson, Les, Xu, Peng, Zhao, Lei, Rambo, Brittany, Hart, John, Xiao, Shu-Yuan, Bengali, Kathleen, Uzzell, Jamar, Darfler, Marlene, Krizman, David B., Cecchi, Fabiola, Bottaro, Donald P., Karrison, Theodore, Veenstra, Timothy D., Hembrough, Todd, Burrows, Jon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077664/
https://ncbi.nlm.nih.gov/pubmed/24983965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100586
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