A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of Type 1 diabetes in NOD mice

To prepare a novel Bispecific Antibody (BsAb) as a potential targeted therapy for T1D, we produced a “functionally inert” monoclonal antibody (mAb) against Glucose transporter-2 (GLUT-2) expressed on β-cells to serve as an anchoring antibody. The therapeutic arm is an agonistic mAb against Cytotoxic...

Full description

Saved in:
Bibliographic Details
Main Authors: Bhattacharya, Palash, Fan, Jilao, Haddad, Christine, Essani, Abdul, Gopisetty, Anupama, Elshabrawy, Hatem A, Vasu, Chenthamarakshan, Prabhakar, Bellur S.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077286/
https://ncbi.nlm.nih.gov/pubmed/24792135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.04.014
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items