A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of Type 1 diabetes in NOD mice

To prepare a novel Bispecific Antibody (BsAb) as a potential targeted therapy for T1D, we produced a “functionally inert” monoclonal antibody (mAb) against Glucose transporter-2 (GLUT-2) expressed on β-cells to serve as an anchoring antibody. The therapeutic arm is an agonistic mAb against Cytotoxic...

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Autori principali: Bhattacharya, Palash, Fan, Jilao, Haddad, Christine, Essani, Abdul, Gopisetty, Anupama, Elshabrawy, Hatem A, Vasu, Chenthamarakshan, Prabhakar, Bellur S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077286/
https://ncbi.nlm.nih.gov/pubmed/24792135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.04.014
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