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Trypsin causes platelet activation independently of known protease-activated receptors
To identify a physiological agonist of PAR3, we used PAR4 null murine platelets, which were known to express only PAR3. In this study, we tested several proteases and found that trypsin, but not heat-inactivated trypsin, activated PAR4 null murine platelets. Even at high concentrations, trypsin caus...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077195/ https://ncbi.nlm.nih.gov/pubmed/24030758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH13-03-0189 |
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