Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC

The E3 ligase ARF-BP1 governs the balance of life and death decisions by directing the degradation of p53 and enhancing the transcriptional activity of MYC. We find B cells selectively deficient in ARF-BP1 have many defects in developing and mature B cells associated with increased expression of p53...

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Detalhes bibliográficos
Main Authors: Qi, Chen-Feng, Zhang, Ruihua, Sun, Jiafang, Li, Zhaoyang, Shin, Dong-Mi, Wang, Hongsheng, Kovalchuk, Alexander L., Sakai, Tomomi, Xiong, Huabao, Kon, Ning, Gu, Wei, Morse, Herbert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077183/
https://ncbi.nlm.nih.gov/pubmed/24199708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.09.009
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