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Involvement of a volatile metabolite during phosphoramide mustard-induced ovotoxicity

The finite ovarian follicle reserve can be negatively impacted by chemical exposures including the anti-neoplastic agent, cyclophosphamide (CPA). CPA requires bioactivation to phosphoramide mustard (PM) to elicit its therapeutic effects however; in addition to being the tumor-targeting metabolite, P...

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Main Authors: Madden, Jill A., Hoyer, Patricia B., Devine, Patrick J., Keating, Aileen F.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077164/
https://ncbi.nlm.nih.gov/pubmed/24642057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2014.03.006
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