Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes

AIM: To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552). METHODS: Methods: Primary astrocyte cultures were prepared from the cortex of postnatal rat pups. An astrocytes model of Huntington's di...

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Bibliographic Details
Main Authors: Chen, Lei-lei, Wu, Jun-chao, Wang, Lin-hui, Wang, Jin, Qin, Zheng-hong, Difiglia, Marian, Lin, Fang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077128/
https://ncbi.nlm.nih.gov/pubmed/22266730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.162
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