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Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease

Pin1 is a unique enzyme that changes the shape of target proteins by acting on specific amino acids that have been phosphorylated: serine or threonine residues that precede proline. Pin1 catalyzes the flip between two distinct orientations, called cis and trans, around the proline bond. This change...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Driver, Jane A., Zhou, Xiao Zhen, Lu, Kun Ping
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076490/
https://ncbi.nlm.nih.gov/pubmed/24534472
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