Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity: NOVEL MECHANISM FOR Pin1 TO PROTECT AGAINST ALZHEIMER DISEASE

Alzheimer disease (AD) is characterized by the presence of senile plaques of amyloid-β (Aβ) peptides derived from amyloid precursor protein (APP) and neurofibrillary tangles made of hyperphosphorylated Tau. Increasing APP gene dosage or expression has been shown to cause familial early-onset AD. How...

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Detalhes bibliográficos
Main Authors: Ma, Suk Ling, Pastorino, Lucia, Zhou, Xiao Zhen, Lu, Kun Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293570/
https://ncbi.nlm.nih.gov/pubmed/22184106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.298596
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