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Sustained Expression of Insulin by a Genetically Engineered Sertoli Cell Line after Allotransplantation in Diabetic BALB/c Mice

Immune-privileged Sertoli cells (SCs) exhibit long-term survival after allotransplantation or xenotransplantation, suggesting they can be used as a vehicle for cell-based gene therapy. Previously, we demonstrated that SCs engineered to secrete insulin by using an adenoviral vector normalized blood g...

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Bibliografski detalji
Glavni autori: Kaur, Gurvinder, Thompson, Lea Ann, Pasham, Mithun, Tessanne, Kim, Long, Charles R., Dufour, Jannette M.
Format: Artigo
Jezik:Inglês
Izdano: Society for the Study of Reproduction, Inc. 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076370/
https://ncbi.nlm.nih.gov/pubmed/24695630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.113.115600
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