Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca(2+) Dependent Fashion to Specifically Regulate Structure and Activity

Clinical studies have demonstrated a correlation between elevated levels of FIX and the risk of coronary heart disease, while reduced plasma FIX causes hemophilia B. FIXa interacts with FVIIIa in the presence of Ca(2+) and phosphatidylserine (PS)-containing membranes to form a factor X-activating co...

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Autores principales: Majumder, Rinku, Koklic, Tilen, Sengupta, Tanusree, Cole, Daud, Chattopadhyay, Rima, Biswas, Subir, Monroe, Dougald, Lentz, Barry R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076177/
https://ncbi.nlm.nih.gov/pubmed/24979705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100006
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