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A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression
It is well-established that over-accumulation of dietary cholesterol in the liver inhibits sterol-regulatory element binding protein (SREBP)-mediated LDL receptor (LDLR) gene transcription leading to a reduced hepatic LDLR mRNA level in hypercholesterolemic animals. However, it is unknown whether el...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4076078/ https://ncbi.nlm.nih.gov/pubmed/24792925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M049429 |
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