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FXR activation by obeticholic acid elevates liver LDL receptor expression by mRNA stabilization and reduces plasma LDL-cholesterol in mice
OBJECTIVE: To determine whether and how activation of farnesoid X receptor (FXR) by obeticholic acid (OCA), a clinical FXR agonist, modulates liver LDL receptor (LDLR) expression under normolipidemic conditions. APPROACH AND RESULTS: Administration of OCA to chow-fed mice increased mRNA and protein...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6206879/ https://ncbi.nlm.nih.gov/pubmed/30354208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311122 |
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