Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding

[Image: see text] α-Synuclein (α-Syn), a major component of Lewy body that is considered as the hallmark of Parkinson’s disease (PD), has been implicated in neuroexocytosis. Overexpression of α-Syn decreases the neurotransmitter release. However, the mechanism by which α-Syn buildup inhibits the neu...

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Autors principals: Lai, Ying, Kim, Sunae, Varkey, Jobin, Lou, Xiaochu, Song, Jae-Kyun, Diao, Jiajie, Langen, Ralf, Shin, Yeon-Kyun
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075992/
https://ncbi.nlm.nih.gov/pubmed/24884175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5002536
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