A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling

BACKGROUND: High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NFκB and Hedgehog (Hh) signaling pathways are involved in the fatal development of castration-resistant prostate cancer during...

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Detalhes bibliográficos
Main Authors: Köhler, Andrea, Demir, Ümmühan, Kickstein, Eva, Krauss, Sybille, Aigner, Johanna, Aranda-Orgillés, Beatriz, Karagiannidis, Antonios I, Achmüller, Clemens, Bu, Huajie, Wunderlich, Andrea, Schweiger, Michal-Ruth, Schaefer, Georg, Schweiger, Susann, Klocker, Helmut, Schneider, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074869/
https://ncbi.nlm.nih.gov/pubmed/24913494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-146
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