Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)

We have shown previously that the ubiquitin ligase MID1, mutations of which cause the midline malformation Opitz BBB/G syndrome (OS), serves as scaffold for a microtubule-associated protein complex that regulates protein phosphatase 2A (PP2A) activity in a ubiquitin-dependent manner. Here, we show t...

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Detalhes bibliográficos
Main Authors: Aranda-Orgillés, Beatriz, Rutschow, Désirée, Zeller, Raphael, Karagiannidis, Antonios I., Köhler, Andrea, Chen, Changwei, Wilson, Timothy, Krause, Sven, Roepcke, Stefan, Lilley, David, Schneider, Rainer, Schweiger, Susann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220588/
https://ncbi.nlm.nih.gov/pubmed/21930711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224451
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