Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related tauopathies and is a crucial factor in the pathogenesis of these disorders. Though diverse kinases have been implicated in tau phosphorylat...

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Detalhes bibliográficos
Main Authors: Kickstein, Eva, Krauss, Sybille, Thornhill, Paul, Rutschow, Désirée, Zeller, Raphael, Sharkey, John, Williamson, Ritchie, Fuchs, Melanie, Köhler, Andrea, Glossmann, Hartmut, Schneider, Rainer, Sutherland, Calum, Schweiger, Susann
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003072/
https://ncbi.nlm.nih.gov/pubmed/21098287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912793107
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