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HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation

Antiestrogens including tamoxifen and fulvestrant have been evaluated as chemotherapeutics for ovarian cancer, particularly in cases of platinum resistant disease. Human epididymis protein 4 (HE4) is highly overexpressed in women with ovarian cancer and overexpression of HE4 has been found to correl...

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Hlavní autoři: Lokich, Elizabeth, Singh, Rakesh K., Han, Alex, Romano, Nicole, Yano, Naohiro, Kim, Kyukwang, Moore, Richard G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074789/
https://ncbi.nlm.nih.gov/pubmed/24975515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05500
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