Caspase-8 Acts as a Molecular Rheostat to Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation()

Caspase-8, an executioner enzyme in the death receptor pathway, has previously been shown to initiate apoptosis and suppress necroptosis. Here, we identify a novel, cell death-independent role for caspase-8 in dendritic cells (DCs); namely, DC-specific expression of caspase-8 prevents the onset of s...

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Main Authors: Cuda, Carla M., Misharin, Alexander V., Gierut, Angelica K., Saber, Rana, Haines, G. Kenneth, Hutcheson, Jack, Hedrick, Stephen M., Mohan, Chandra, Budinger, G. Scott, Stehlik, Christian, Perlman, Harris
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074511/
https://ncbi.nlm.nih.gov/pubmed/24808358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400122
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