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Computational Delineation of Tyrosyl-Substrate Recognition and Catalytic Landscapes in the Epidermal Growth Factor Receptor Tyrosine Kinase Domain

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK), which catalyzes protein phosphorylation reactions by transferring the γ-phosphoryl group from an ATP molecule to the hydroxyl group of tyrosine residues in protein substrates. EGFR is an important drug target in the tre...

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Bibliografiske detaljer
Main Authors: Liu, Yingting, Radhakrishnan, Ravi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074314/
https://ncbi.nlm.nih.gov/pubmed/24779031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mb70620f
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