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Computational Delineation of Tyrosyl-Substrate Recognition and Catalytic Landscapes in the Epidermal Growth Factor Receptor Tyrosine Kinase Domain
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK), which catalyzes protein phosphorylation reactions by transferring the γ-phosphoryl group from an ATP molecule to the hydroxyl group of tyrosine residues in protein substrates. EGFR is an important drug target in the tre...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074314/ https://ncbi.nlm.nih.gov/pubmed/24779031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mb70620f |
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