Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes

Human pluripotent stem cells (hPSCs) represent a novel source of hepatocytes for drug metabolism studies and cell-based therapy for the treatment of liver diseases. These applications are, however, dependent on the ability to generate mature metabolically functional cells from the hPSCs. Reproducibl...

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Bibliographische Detailangaben
Hauptverfasser: Ogawa, Shinichiro, Surapisitchat, James, Virtanen, Carl, Ogawa, Mina, Niapour, Maryam, Sugamori, Kim S., Wang, Shuang, Tamblyn, Laura, Guillemette, Chantal, Hoffmann, Ewa, Zhao, Bin, Strom, Stephen, Laposa, Rebecca R., Tyndale, Rachel F., Grant, Denis M., Keller, Gordon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074277/
https://ncbi.nlm.nih.gov/pubmed/23861064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.090266
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