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Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4(+) T Cell Responses

Antigen specificity is critical in immune response and requires integration of antigen-specific signals with antigen-nonspecific signals such as those provided by cytokines. The mechanism integrating these pathways is incompletely understood. We report here that antigen-specific proliferative respon...

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Detalhes bibliográficos
Main Authors: Watanabe, Masashi, Moon, Kyung Duk, Vacchio, Melanie S., Hathcock, Karen S., Hodes, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073799/
https://ncbi.nlm.nih.gov/pubmed/24792911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.006
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