Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non–small cell lung cancer

BACKGROUND: When presenting with advanced stage disease, lung cancer patients have <5% 5-y survival. The overexpression of checkpoint kinase 1 (CHK1) is associated with poorer outcomes and may contribute to therapy resistance. Targeting CHK1 with small-molecule inhibitors in p53 mutant tumors mig...

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Hlavní autoři: Grabauskiene, Svetlana, Bergeron, Edward J., Chen, Guoan, Thomas, Dafydd G., Giordano, Thomas J., Beer, David G., Morgan, Meredith A., Reddy, Rishindra M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073630/
https://ncbi.nlm.nih.gov/pubmed/24418519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.12.016
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