Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer

PURPOSE: Estrogen receptor-α (ERα) targeted therapies including tamoxifen (TAM) or Faslodex (ICI) are used to treat ER+ breast cancers. Up to 50% of tumors will acquire resistance to these interventions. Autophagy has been implicated as a major driver of antiestrogen resistance. We have explored the...

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Huvudupphovsmän: Cook, Katherine L., Wärri, Anni, Soto-Pantoja, David R., Clarke, Pamela A.G., Cruz, M. Idalia, Zwart, Alan, Clarke, Robert
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073207/
https://ncbi.nlm.nih.gov/pubmed/24928945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3227
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