Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis

BACKGROUND: RNA interference (RNAi) is an effective and important tool used to study gene function. For large-scale screens, RNAi is used to systematically down-regulate genes of interest and analyze their roles in a biological process. However, RNAi is associated with off-target effects (OTEs), inc...

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Autori principali: Yilmazel, Bahar, Hu, Yanhui, Sigoillot, Frederic, Smith, Jennifer A, Shamu, Caroline E, Perrimon, Norbert, Mohr, Stephanie E
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073188/
https://ncbi.nlm.nih.gov/pubmed/24934636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-192
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