Lentiviral and targeted cellular barcoding reveals ongoing clonal dynamics of cell lines in vitro and in vivo

BACKGROUND: Cell lines are often regarded as clonal, even though this simplifies what is known about mutagenesis, transformation and other processes that destabilize them over time. Monitoring these clonal dynamics is important for multiple areas of biomedical research, including stem cell and cance...

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Detalhes bibliográficos
Main Authors: Porter, Shaina N, Baker, Lee C, Mittelman, David, Porteus, Matthew H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073073/
https://ncbi.nlm.nih.gov/pubmed/24886633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-5-r75
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