Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer

Eitemau Tebyg

• Estradiol Stimulates Glucose Metabolism via 6-Phosphofructo-2-kinase (PFKFB3)
  gan: Imbert-Fernandez, Yoannis, et al.
  Cyhoeddwyd: (2014)
• Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
  gan: Klarer, Alden C, et al.
  Cyhoeddwyd: (2014)
• Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth
  gan: Chesney, Jason, et al.
  Cyhoeddwyd: (2014)
• Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non–small cell lung cancer cell survival
  gan: Lypova, Nadiia, et al.
  Cyhoeddwyd: (2019)
• Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer
  gan: Clem, Brian F., et al.
  Cyhoeddwyd: (2013)