Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

BACKGROUND: Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from fructose-2,6-bisphosphate, a key regulator of the glycolytic enzyme phosphofruct...

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Bibliographische Detailangaben
Hauptverfasser: Klarer, Alden C, O’Neal, Julie, Imbert-Fernandez, Yoannis, Clem, Amy, Ellis, Steve R, Clark, Jennifer, Clem, Brian, Chesney, Jason, Telang, Sucheta
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913946/
https://ncbi.nlm.nih.gov/pubmed/24451478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-2-2
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