Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isolated from patients with virulent invasive diseases. W...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mayfield, Jeffrey A., Liang, Zhong, Agrahari, Garima, Lee, Shaun W., Donahue, Deborah L., Ploplis, Victoria A., Castellino, Francis J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072638/
https://ncbi.nlm.nih.gov/pubmed/24968349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100698
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