Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isolated from patients with virulent invasive diseases. W...

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Detalhes bibliográficos
Main Authors: Mayfield, Jeffrey A., Liang, Zhong, Agrahari, Garima, Lee, Shaun W., Donahue, Deborah L., Ploplis, Victoria A., Castellino, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072638/
https://ncbi.nlm.nih.gov/pubmed/24968349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100698
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