Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H(+)-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging sympt...

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Detalhes bibliográficos
Main Authors: Sasaki, Tomoyuki, Lian, Shanshan, Qi, Jie, Bayliss, Peter E., Carr, Christopher E., Johnson, Jennifer L., Guha, Sujay, Kobler, Patrick, Catz, Sergio D., Gill, Matthew, Jia, Kailiang, Klionsky, Daniel J., Kishi, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072523/
https://ncbi.nlm.nih.gov/pubmed/24967584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004409
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