Acquired pMHC I Complexes Greatly Enhance CD4(+) Th Cell's Stimulatory Effect on CD8(+) T Cell-Mediated Diabetes in Transgenic RIP-mOVA Mice

CD4(+) helper T (Th) cells play pivotal roles in induction of CD8(+) CTL immunity. However, the mechanism of CD4(+) T cell help delivery to CD8(+) T cells in vivo is still elusive. In this study, we used ovalbumin (OVA)-pulsed dendritic cells (DC(OVA)) to activate OT-II mouse CD4(+) T cells, and the...

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Main Authors: Ahmed, Khawaja Ashfaque, Xie, Yufeng, Zhang, Xueshu, Xiang, Jim
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072405/
https://ncbi.nlm.nih.gov/pubmed/19118506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2008.51
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