Peptide–MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites

T cells generate adaptive immune responses mediated by the T cell receptor (TCR)–CD3 complex comprising an αβ TCR heterodimer noncovalently associated with three CD3 dimers. In early T cell activation, αβ TCR engagement by peptide–major histocompatibility complex (pMHC) is first communicated to the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rangarajan, Sneha, He, Yanan, Chen, Yihong, Kerzic, Melissa C., Ma, Buyong, Gowthaman, Ragul, Pierce, Brian G., Nussinov, Ruth, Mariuzza, Roy A., Orban, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187629/
https://ncbi.nlm.nih.gov/pubmed/30135211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003832
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