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The Ubiquitin-Conjugating Enzyme, UbcM2, Is Restricted to Monoubiquitylation by a Two-Fold Mechanism That Involves Backside Residues of E2 and Lys48 of Ubiquitin
[Image: see text] Proteins can be modified on lysines (K) with a single ubiquitin (Ub) or with polymers of Ub (polyUb). These different configurations and their respective topologies are primary factors for determining whether substrates are targeted to the proteasome for degradation or directed to...
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| Asıl Yazarlar: | , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American
Chemical Society
2014
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4072368/ https://ncbi.nlm.nih.gov/pubmed/24901938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500072v |
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