The Ubiquitin-Conjugating Enzyme, UbcM2, Is Restricted to Monoubiquitylation by a Two-Fold Mechanism That Involves Backside Residues of E2 and Lys48 of Ubiquitin

[Image: see text] Proteins can be modified on lysines (K) with a single ubiquitin (Ub) or with polymers of Ub (polyUb). These different configurations and their respective topologies are primary factors for determining whether substrates are targeted to the proteasome for degradation or directed to...

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Main Authors: Nguyen, Linda, Plafker, Kendra S., Starnes, Andrew, Cook, Matt, Klevit, Rachel E., Plafker, Scott M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072368/
https://ncbi.nlm.nih.gov/pubmed/24901938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500072v
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