The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2

The transcription factor nuclear factor E2-related factor 2 (Nrf2) induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis. Nrf2 is constitutively degraded by the ubiquitin proteolytic system in unperturbed cells, but this turnover is...

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Bibliographic Details
Main Authors: Plafker, Kendra S., Nguyen, Linda, Barneche, Mark, Mirza, Saima, Crawford, David, Plafker, Scott M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906300/
https://ncbi.nlm.nih.gov/pubmed/20484052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121913
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