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Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1
Carbapenem antibiotics are often the “last resort” in the treatment of infections caused by bacteria resistant to penicillins and cephalosporins. To understand why meropenem is resistant to hydrolysis by the SHV-1 class A β-lactamase, the atomic structure of meropenem inactivated SHV-1 was solved to...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071967/ https://ncbi.nlm.nih.gov/pubmed/18761444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja7111146 |
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