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A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxicity: potential for an individualized medicine approach
5-Fluorouracil (5-FU) is commonly administered as a therapeutic agent for the treatment of various aggressive cancers. Severe toxicity to 5-FU has been associated with decreased levels of dihydropyrimidine dehydrogenase (DPD) enzyme activity. Manifestations of 5-FU toxicity typically include cytopen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071869/ https://ncbi.nlm.nih.gov/pubmed/24388031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mayocp.2013.09.008 |
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