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Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents

Pure compound screening has previously identified the indolglyoxylamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC(50) 59 and 44 μM, respectively) and Plasmodium falciparum (K1 dual drug resistant strain) (IC(50) 41...

詳細記述

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書誌詳細
主要な著者: Wang, Jiayi, Kaiser, Marcel, Copp, Brent R.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071569/
https://ncbi.nlm.nih.gov/pubmed/24879541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12063138
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