Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

Cellular senescence is a crucial tumor suppressor mechanism. We discovered a CAPERα/TBX3 repressor complex required to prevent senescence in primary cells and mouse embryos. Critical, previously unknown roles for CAPERα in controlling cell proliferation are manifest in an obligatory interaction with...

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Autori principali: Kumar P, Pavan, Emechebe, Uchenna, Smith, Richard, Franklin, Sarah, Moore, Barry, Yandell, Mark, Lessnick, Stephen L, Moon, Anne M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071561/
https://ncbi.nlm.nih.gov/pubmed/24876127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02805
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