α–Intercalated cells defend the urinary system from bacterial infection

α–Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the defense against urinary infections. In a murine urinary tract infection model, A-ICs bound uropathogenic E. c...

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Main Authors: Paragas, Neal, Kulkarni, Ritwij, Werth, Max, Schmidt-Ott, Kai M., Forster, Catherine, Deng, Rong, Zhang, Qingyin, Singer, Eugenia, Klose, Alexander D., Shen, Tian Huai, Francis, Kevin P., Ray, Sunetra, Vijayakumar, Soundarapandian, Seward, Samuel, Bovino, Mary E., Xu, Katherine, Takabe, Yared, Amaral, Fábio E., Mohan, Sumit, Wax, Rebecca, Corbin, Kaitlyn, Sanna-Cherchi, Simone, Mori, Kiyoshi, Johnson, Lynne, Nickolas, Thomas, D’Agati, Vivette, Lin, Chyuan-Sheng, Qiu, Andong, Al-Awqati, Qais, Ratner, Adam J., Barasch, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071397/
https://ncbi.nlm.nih.gov/pubmed/24937428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71630
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