α–Intercalated cells defend the urinary system from bacterial infection

α–Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the defense against urinary infections. In a murine urinary tract infection model, A-ICs bound uropathogenic E. c...

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Detalhes bibliográficos
Main Authors: Paragas, Neal, Kulkarni, Ritwij, Werth, Max, Schmidt-Ott, Kai M., Forster, Catherine, Deng, Rong, Zhang, Qingyin, Singer, Eugenia, Klose, Alexander D., Shen, Tian Huai, Francis, Kevin P., Ray, Sunetra, Vijayakumar, Soundarapandian, Seward, Samuel, Bovino, Mary E., Xu, Katherine, Takabe, Yared, Amaral, Fábio E., Mohan, Sumit, Wax, Rebecca, Corbin, Kaitlyn, Sanna-Cherchi, Simone, Mori, Kiyoshi, Johnson, Lynne, Nickolas, Thomas, D’Agati, Vivette, Lin, Chyuan-Sheng, Qiu, Andong, Al-Awqati, Qais, Ratner, Adam J., Barasch, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071397/
https://ncbi.nlm.nih.gov/pubmed/24937428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71630
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