Deconstructing the peptide-MHC specificity of T cell recognition

In order to survey a universe of MHC-presented peptide antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors (TCRs) are thought to be cross-reactive. However, the nature and extent of TCR cross-reactivity has not been conclusively measured experimentally. We...

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Huvudupphovsmän: Birnbaum, Michael E., Mendoza, Juan L., Sethi, Dhruv K., Dong, Shen, Glanville, Jacob, Dobbins, Jessica, Özkan, Engin, Davis, Mark M., Wucherpfennig, Kai W., Garcia, K. Christopher
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071348/
https://ncbi.nlm.nih.gov/pubmed/24855945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.047
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