Fatty Acid Synthase Inhibitors Induce Apoptosis in Non-Tumorigenic Melan-A Cells Associated with Inhibition of Mitochondrial Respiration

The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in which the level of FASN expression i...

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Bibliografiska uppgifter
Huvudupphovsmän: Rossato, Franco A., Zecchin, Karina G., La Guardia, Paolo G., Ortega, Rose M., Alberici, Luciane C., Costa, Rute A. P., Catharino, Rodrigo R., Graner, Edgard, Castilho, Roger F., Vercesi, Aníbal E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071076/
https://ncbi.nlm.nih.gov/pubmed/24964211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101060
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